Immunocore holds multi-target discovery partnerships with Genentech, GlaxoSmithKline and AstraZeneca (MedImmune), to develop novel cancer therapies using Immunocore’s ImmTAC technology. A fourth partnership with Eli Lilly, includes a co-development option in addition to ImmTAC co-discovery. Recently, the Bill and Melinda Gates Foundation invested up to $40 million to support the development of ImmTAV and ImmTAB therapeutics for infectious diseases.
In addition to their use as monotherapies, due to their excellent safety profile, ImmTAC molecules are expected to prove valuable in combination with other immunotherapy mechanisms leading to synergistic efficacies and hence potentially improved overall survival and response rates. For example, ImmTAC molecules have the potential to drive circulating T cells to infiltrate tumours whilst checkpoint inhibitors restrict the mechanisms cancers use to try and suppress T cell activity, leading to a synergistic effect.
Immunocore is conducting a clinical combination study with MedImmune, the biologics divistion of AstraZeneca, combining IMCgp100 with checkpoint inhibitors Imfinzi (durvalumab) and tremelimumab in patients with metastatic cutaneous melanoma who are refractory to anti-PD-1 therapies. More recently, Immunocore also entered into an immunotherapy-based clinical trial collaboration with Lilly to explore the utility of IMCgp100, in combination with Lilly’s merestinib (LY2801653) for the treatment of metastatic uveal melanoma
Immunocore has an interest in relevant technologies and will seek to license and acquire technologies that enhance existing programmes and create new opportunities.
For further information about partnering and licensing opportunities, please contact Immunocore’s Business Development group at bus.dev@immunocore.com.
